What is done differently for network calls in debug mode vs non debug mode?

I have a React Native app that I have built and tested. On iOS, through the expo client the network calls are made successfully without issue but on Android, all network calls result in a “Network Error”. When I run the app in debug mode in the expo client, all network calls are made successfully without issue in Android as well.

I am trying to get to the root of this issue and to do so need to understand what is being done differently in debug mode that is allowing the call to be made successfully. Is there an expo-android configuration that I need to which I am missing?

Thanks!